MED 13‐dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver
نویسندگان
چکیده
منابع مشابه
MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver
The heart requires a continuous supply of energy but has little capacity for energy storage and thus relies on exogenous metabolic sources. We previously showed that cardiac MED13 modulates systemic energy homeostasis in mice. Here, we sought to define the extra-cardiac tissue(s) that respond to cardiac MED13 signaling. We show that cardiac overexpression of MED13 in transgenic (MED13cTg) mice ...
متن کاملAdipose tissue and cholesterol metabolism.
Adipose tissue in man is a major site for cholesterol storage. In obesity over half of total body cholesterol may reside within this tissue; however, relatively little attention has been directed toward understanding the cholesterol metabolism and its relationship to whole body cholesterol homeostasis in this tissue. In this review the factors which influence cholesterol storage are discussed, ...
متن کاملThe metabolism of adipose tissue in vitro
A l t h o u g h the vital role of adipose tissue as a reservoir of fat which can be mobilized to provide energy has long been recognized, it was assumed until relatively recently that the tissue is to a large extent metabolically inert. By 1948 there was available a considerable body of data derived from physiological studies which indicated that adipose tissue is not an inactive storehouse. ...
متن کاملDivergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling.
Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white adipose tissue (WAT) in rats. We used 10-month-old male, wild-type (W) Wistar ...
متن کاملMetabolism of Mamose and Glucose by Adipose Tissue and Liver Slices from Normal and Alloxan-diabetic Rats*
The ability of mannose to substitute for glucose in metabolic reactions has been known for over 40 years. In 1913 Levine and Meyer (1,2) reported the ability of preparations of canine leukocytes and rabbit kidney to convert either hexose to d-lactic acid. Since then, with the use of parameters which have included hexose uptake or phosphorylation, tissue respiration, lactic acid production, or s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2014
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201404218